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Lamotrigine (hydrate)

CAT: 0804-HY-B0495ASize: 1 EachDry Ice: NoHazardous: No
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Description
Lamotrigine hydrate is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine hydrate selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine hydrate can be used for the research of epilepsy, focal seizure, et al[1][2].
CAS Number
375347-20-9
Product Name Alternative
LTG (hydrate) ; BW430C (hydrate)
UNSPSC
12352005
Target
Autophagy; Sodium Channel
Type
Reference compound
Related Pathways
Autophagy; Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/lamotrigine-hydrate.html
Solubility
10 mM in DMSO
Smiles
NC1=NC(N)=C(C2=CC=CC(Cl)=C2Cl)N=N1.O
Molecular Formula
C9H9Cl2N5O
Molecular Weight
274.11
References & Citations
[1]M J Leach, et al. Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: II. Neurochemical studies on the mechanism of action. Epilepsia. Sep-Oct 1986;27 (5) :490-7.|[2]Damianka P Getova, et al. A study of the effects of lamotrigine on mice using two convulsive tests. Folia Med (Plovdiv) . Apr-Jun 2011;53 (2) :57-62.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

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