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Quinaprilat (hydrate)

CAT: 0804-HY-127026ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-127026ASize:1 Each
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Description
Quinaprilat hydrate is a non-mercapto Angiotensin Converting Enzyme (ACE) inhibitor, the active metabolite of Quinapril. Quinaprilat hydrate specifically blocks the conversion of angiotensin I to the vasoconstrictor angiotensin II and inhibits the degradation of bradykinin. Quinaprilat hydrate acts as anti-hypertensive agent and vasodilator[1][2].
CAS Number
1435786-09-6
UNSPSC
12352005
Target
Angiotensin-converting Enzyme (ACE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/quinaprilat-hydrate.html
Solubility
10 mM in DMSO
Smiles
O=C(O)[C@H]1N(CC2=C(C1)C=CC=C2)C([C@H](C)N[C@@H](CCC3=CC=CC=C3)C(O)=O)=O.O
Molecular Formula
C23H28N2O6
Molecular Weight
428.48
References & Citations
[1]Haodan Yuan, et al. Renal organic anion transporter-mediated drug-drug interaction between gemcabene and quinapril. J Pharmacol Exp Ther. 2009 Jul;330 (1) :191-7. doi: 10.1124/jpet.108.149476. Epub 2009 Apr 6|[2]Sinisa Stanisavljevic, et al. Angiotensin I-converting enzyme inhibitors block protein kinase C epsilon by activating bradykinin B1 receptors in human endothelial cells. J Pharmacol Exp Ther. 2006 Mar;316 (3) :1153-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

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