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CHAPS (hydrate)

CAT: 0804-HY-15435A-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15435A-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CHAPS hydrate is a non-covalent reversible stabilizer of nucleosomes derived from Cholic Acid. CHAPS hydrate can stabilize the ultrastructure of nucleosomes, inhibit the spontaneous dissociation of nucleosomes at low concentrations, and maintain the integrity of the basic structural units of chromatin. CHAPS hydrate can promote the sliding of histone cores along the DNA chain and reduce sequence-specific binding. CHAPS hydrate can also be used as a zwitterionic detergent to dissolve membrane proteins, stabilize various protein-DNA complexes, and retain the biochemical activity of proteins in solution[1][2].
CAS Number
331717-45-4
UNSPSC
12352200
Hazard Statement
H302, H315, H319, H335
Target
Biochemical Assay Reagents
Type
Biochemical Assay Reagents
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/chaps-hydrate.html
Purity
98.0
Solubility
DMSO : 10.87 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O[C@H]1[C@@]2([H])[C@@]3([H])[C@@]([C@@](CC3)([H])[C@H](C)CCC(NCCC[N+](C)(C)CCCS(=O)([O-])=O)=O)([C@H](C[C@]2([H])[C@@]4([C@](C[C@@H](CC4)O)([H])C1)C)O)C.O
Molecular Formula
C32H60N2O8S
Molecular Weight
632.89
Precautions
H302, H315, H319, H335
References & Citations
[1]Kroflic A, et al. Thermodynamic characterization of 3-[ (3-cholamidopropyl) -dimethylammonium]-1-propanesulfonate (CHAPS) micellization using isothermal titration calorimetry: temperature, salt, and pH dependence. Langmuir. 2012 Jul 17;28 (28) :10363-71.|[2]Menshikova I, et al. Nucleosomes structure and dynamics: effect of CHAPS. Int J Biochem Mol Biol. 2011;2 (2) :129-137.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Biochemical Assay Reagents
Clinical Information
No Development Reported

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