Idoxuridine (hydrate)

CAT: 0804-HY-B0307ASize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-B0307ASize:1 Each
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Description
Idoxuridine (5-Iodo-2′-deoxyuridine, 5-IUdR, IdUrd) hydrate is an iodinated thymidine analogue that competitively inhibits phosphorylases. Idoxuridine can inhibit viral activity, particularly viral eye infections, including herpes simplex keratitis, by inhibiting DNA polymerase and affecting viral replication. Idoxuridine against feline herpesvirus has the IC50 value of 4.3 μM[1].
CAS Number
[17140-71-5]
Product Name Alternative
5-Iodo-2′-deoxyuridine (hydrate) ; 5-IUdR (hydrate) ; IdUrd (hydrate)
UNSPSC
12352005
Target
Phosphatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection; Cancer
Assay Protocol
https://www.medchemexpress.com/idoxuridine-hydrate.html
Solubility
10 mM in DMSO
Smiles
OC[C@@H]1[C@H](C[C@H](N2C(NC(C(I)=C2)=O)=O)O1)O.O
Molecular Formula
C9H13IN2O6
Molecular Weight
372.11
References & Citations
[1]]David J Maggs, et al. In vitro efficacy of ganciclovir, cidofovir, penciclovir, foscarnet, idoxuridine, and acyclovir against feline herpesvirus type-1. Am J Vet Res. 2004 Apr;65 (4) :399-403.|[2]D E Griswold, et al. Stimulation of hemolysin plaque-forming cells by idoxuridine. Cancer Res. 1975 Jan;35 (1) :88-92.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

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