Edonentan (hydrate)

• Description:

  Edonentan (BMS 207940) hydrate is a potent and selective antagonist of the endothelin A (ETA) receptor, with a Ki of 10 pM. In rats, Edonentan has superior (100%) oral bioavailbility[1].

• Product Name Alternative:

  BMS 207940 (hydrate)

• UNSPSC:

  12352005

• Target:

  Endothelin Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/edonentan-hydrate.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC(C)(C)CC(N(CC1=CC(C2=NC=CO2)=CC=C1C3=CC=CC=C3S(=O)(NC4=NOC(C)=C4C)=O)C)=O.O

• Molecular Formula:

  C28H34N4O6S

• Molecular Weight:

  554.66

• References & Citations:

  [1]Murugesan N, et al. Biphenylsulfonamide endothelin receptor antagonists. 4. Discovery of N-[[2'-[[ (4,5-dimethyl-3-isoxazolyl) amino]sulfonyl]-4- (2-oxazolyl) [1,1'-biphenyl]- 2-yl]methyl]-N,3,3-trimethylbutanamide (BMS-207940), a highly potent and orally active ET (A) selective antagonist. J Med Chem. 2003 Jan 2;46 (1) :125-37.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• Isoform:

  ETA

• CAS Number:

  [264609-13-4]