Products for Research Use Only
RegisterLogin

Fenobam (hydrate)

CAT: 0804-HY-101478ASize: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-101478ASize:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Fenobam hydrate is a selective and orally active mGluR5 antagonist (IC50=84 nM) that can penetrate the blood-brain barrier. Fenobam hydrate shows the Kd values of 54 nM and 31 nM on rat and human recombinant mGlu5 receptors, respectively. Fenobam hydrate has anxiolytic activity, inhibits self-administration behavior in rat, and induces apoptosis in cancer cells. Fenobam hydrate can be used for research on neurological diseases, cancer and drug addiction[1][2][3].
CAS Number
63540-28-3
UNSPSC
12352005
Target
Apoptosis; mGluR
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/fenobam-hydrate.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=NC(CN1C)=O)NC2=CC=CC(Cl)=C2.O
Molecular Formula
C11H13ClN4O3
Molecular Weight
284.70
References & Citations
[1]Porter RH, et al. Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity. J Pharmacol Exp Ther. 2005 Nov;315 (2) :711-21.|[2]Liao S, et al. Osteosarcoma cell proliferation and survival requires mGluR5 receptor activity and is blocked by Riluzole. PLoS One. 2017 Feb 23;12 (2) :e0171256.|[3]Keck TM, et al. Fenobam sulfate inhibits cocaine-taking and cocaine-seeking behavior in rats: implications for addiction treatment in humans. Psychopharmacology (Berl) . 2013;229 (2) :253-265.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
MGluR5

Related Products

CatalogName
HY-101478-01Fenobam
HY-101478RFenobam (Standard)
HY-127018AMaltoheptaose (hydrate)
HY-112467Tivozanib (hydrate)
HY-B0117D-01Tigecycline (hydrate)
HY-N0153ANaringin (hydrate)
HY-N0355-01(+) -Catechin hydrate
HY-145015ATuspetinib (hydrate)
HY-D0858C-01MES (hydrate)
HY-B0307AIdoxuridine (hydrate)

Alternative Products

CatalogName
NCA54028-01Fenobam (hydrate)
MBS5811514Fenobam hydrate
B7035-50Fenobam
A20372-200Fenobam 200mg
A20372-25Fenobam 25mg
A20372-10Fenobam 10mg
A20372-100Fenobam 100mg
A20372-50Fenobam 50mg
A20372-5Fenobam 5mg
A20372-1Fenobam 1mg

Popular Products