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AChE/BChE-IN-25

CAT: 0804-HY-168731Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168731Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AChE/BChE-IN-25 (Compound 6e) is the orally active inhibitor for hAChE and eqBChE with IC50 of 7.9 nM and 0.79 nM. AChE/BChE-IN-25 exhibits antioxidant activity, that scavenges free radical with IC50 of 22.91 μM. AChE/BChE-IN-25 exhibits neuroprotective effects by reducing mitochondrial and cellular oxidative stress in the Drosophila Alzheimer's disease model. AChE/BChE-IN-25 ameliorates Scopolamine -induced spatial and cognitive memory impairment in mouse model[1].
UNSPSC
12352211
Target
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ache-bche-in-25.html
Smiles
O=C(NCCC1=CNC2=C1C=C(Cl)C=C2)OC3=CC([C@H](C)N(C)C)=CC=C3
Molecular Formula
C21H24ClN3O2
Molecular Weight
385.89
References & Citations
[1]Shankar G, et al., Discovery of novel hybrid tryptamine-rivastigmine molecules as potent AChE and BChE inhibitors exhibiting multifunctional properties for the management of Alzheimer's disease. Eur J Med Chem. 2024 Nov 27;283:117066.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BChE

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