Amgen-23

• Description :

  Amgen-23 (compound 23) is a potent sphingosine kinases (SPHK) inhibitor with IC50 values of 20 nM and 1.6 μM for SPHK1 and SPHK2, respectively. Amgen-23 can be used for researching anticancer[1].

• CAS Number :

  [1448706-15-7]

• UNSPSC :

  12352005

• Target :

  SphK

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/amgen-23.html

• Purity :

  98.11

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  ClC(C=C1C2=CSC(NC3=CC=C(C=C3)CCN4[C@H](C[C@H](CC4)O)CO)=N2)=C(C=C1)Cl

• Molecular Formula :

  C23H25Cl2N3O2S

• Molecular Weight :

  478.43

• References & Citations :

  [1]Gustin DJ, et al. Structure guided design of a series of sphingosine kinase (SphK) inhibitors. Bioorg Med Chem Lett. 2013 Aug 15;23 (16) :4608-16.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  SphK1; SphK2