ZYH-23

• Description:

  ZYH-23 is a potent necroptosis inhibitor. ZYH-23 blocks necroptosis by inhibiting RIPK1, RIPK3, and MLKL phosphorylation via HSP90 targeting[1].

• UNSPSC:

  12352005

• Target:

  Necroptosis

• Related Pathways:

  Apoptosis

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Inflammation/Immunology

• Smiles:

  O=C1C(C#N)=C[C@]2([C@]([H])(C1(C)C)CC[C@](C)(C2=CC3=O)[C@]4([C@]3([C@]5([C@@](C(NC6=CC=C(C=C6)C7=NN(C=C7)C)=O)(CC4)CCC(C)(C5)C)[H])[H])C)C

• Molecular Formula:

  C41H50N4O3

• Molecular Weight:

  646.86

• References & Citations:

  [1]Zou Y, et al. Bardoxolone Derivatives as Novel Pseudo-Natural Necroptosis Inhibitors by Destabilizing HSP90 Client Proteins. J Med Chem. 2025 May 22;68 (10) :9906-9925.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported