HER2-IN-23

• Description :

  HER2-IN-23 is a selective HER2 inhibitor. HER2-IN-23 reduces in total HER2 expression rather than in phosphorylated HER2 (p-HER2) . HER2-IN-23 reduces cyclin D1 level and stimulates PARP cleavage. HER2-IN-23 can be used for the study of HER2-positive breast cancer[1].

• UNSPSC :

  12352005

• Target :

  EGFR; PARP

• Related Pathways :

  Cell Cycle/DNA Damage; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

• Field of Research :

  Cancer

• Smiles :

  O=C1C(C2=CC=C(OCC3=CC=CC(F)=C3)C(Cl)=C2)=COC4=C1C(CCC4)=O

• Molecular Formula :

  C22H16ClFO4

• Molecular Weight :

  398.81

• References & Citations :

  [1]Rubinov DB, et al. A facile method for the preparation of 7,8-dihydro-4H-chromene-4,5 (6H) -diones as non-aromatic cycle A analogs of isoflavones and their evaluation as antiproliferative agents. Bioorg Chem. 2025 Oct;165:108960.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported