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XDS-23

CAT: 0804-HY-179389Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179389Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
XDS-23 is a selective biofilm inhibitor with an IC50 of 1.26 µM against Pseudomonas aeruginosa. XDS-23 exerts a dual inhibitory effect on the LasI/LasR System (las) and Pseudomonas Quinolone Signal System (pqs) . XDS-23 suppress the production of key virulence factors including elastase, pyocyanin, and extracellular polysaccharides. XDS-23 exhibits synergistic antibacterial activity and can enhance the efficacy of multiple antibiotics in both in vitro and in vivo models, while maintaining a favorable safety profile. XDS-23 can be employed for research in combating biofilm-mediated drug-resistant P. aeruginosa infections[1].
UNSPSC
12352005
Target
Bacterial; Elastase; Glutathione S-transferase
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Smiles
CCCCNC(COC(C1=CC(Cl)=CC=C1O2)=CC2=O)=O
Molecular Formula
C15H16ClNO4
Molecular Weight
309.74
References & Citations
[1]Liu W, et al, synthesis and biological evaluation of novel coumarin derivatives as Pseudomonas aeruginosa biofilm inhibitors. Eur J Med Chem. 2026 Jan 15;302 (Pt 1) :118294.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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