MK-8719

• Description :

  MK-8719 is a highly potent and selective O-GlcNAcase (OGA) inhibitor (Ki=7.9 nM for hOGA) with excellent CNS penetration[1].

• UNSPSC :

  12352005

• Target :

  OGA

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/mk-8719.html

• Purity :

  99.55

• Solubility :

  DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 6.67 mg/mL

• Smiles :

  O[C@H]1[C@H](O)[C@@]2([H])N=C(NCC)S[C@@]2([H])O[C@@H]1C(F)F

• Molecular Formula :

  C9H14F2N2O3S

• Molecular Weight :

  268.29

• References & Citations :

  [1]Selnick HG, et al. Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies. J Med Chem. 2019 Sep 29.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• CAS Number :

  [1382799-40-7]