Bcl-2-IN-22

Bcl-2-IN-22

• UNSPSC Description: Bcl-2-IN-22 (compound 1) is a gold(I) NHC complex with anticancer activity. Bcl-2-IN-22 induces apoptosis via the mitochondrial pathway with an IC50 value of 0.014 μM. In addition, Bcl-2-IN-22 targets BCL-2 family members and exhibits pro-apoptosis and resensitization properties in multidrug-resistant leukemia cells that overexpress BCL-2[1].
• Target Antigen: Apoptosis; Bcl-2 Family
• Type: Reference compound
• Related Pathways: Apoptosis
• Field of Research: cancer
• Assay Protocol: https://www.medchemexpress.com/bcl-2-in-22.html
• Smiles: CC1=CC(C)=CC(C)=C1[N]2=NC([Au+]C3N=[N](C4=C(C)C=C(C)C=C4C)N=[N]3C5=C(C)C=C(C)C=C5C)[N](C6=C(C)C=C(C)C=C6C)=N2.[F-][P+5]([F-])([F-])([F-])([F-])[F-]
• Molecular Weight: 956.76
• References & Citations: [1]Bannwart, et al. "A New Class of Gold (I) NHC Complexes with Proapoptotic and Resensitizing Properties towards Multidrug Resistant Leukemia Cells Overexpressing BCL-2." Journal of Medicinal Chemistry (2024).
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported