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Bcl-2-IN-22

CAT: 0804-HY-169083Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-169083Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Bcl-2-IN-22 (compound 1) is a gold (I) NHC complex with anticancer activity. Bcl-2-IN-22 induces apoptosis via the mitochondrial pathway with an IC50 value of 0.014 μM. In addition, Bcl-2-IN-22 targets BCL-2 family members and exhibits pro-apoptosis and resensitization properties in multidrug-resistant leukemia cells that overexpress BCL-2[1].
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bcl-2-in-22.html
Smiles
CC1=CC(C)=CC(C)=C1[N]2=NC([Au+]C3N=[N](C4=C(C)C=C(C)C=C4C)N=[N]3C5=C(C)C=C(C)C=C5C)[N](C6=C(C)C=C(C)C=C6C)=N2.[F-][P+5]([F-])([F-])([F-])([F-])[F-]
Molecular Formula
C38H46AuF6N8P
Molecular Weight
956.76
References & Citations
[1]Bannwart, et al. "A New Class of Gold (I) NHC Complexes with Proapoptotic and Resensitizing Properties towards Multidrug Resistant Leukemia Cells Overexpressing BCL-2." Journal of Medicinal Chemistry (2024) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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