BMS-193885

• Description :

  BMS-193885 is a selective neuropeptide Y1 receptor antagonist (Ki=3.3 nM) that competitively blocks the receptor to inhibit NPY-mediated appetite regulation signaling pathways, reduce food intake and inhibit weight gain. BMS-193885 has good blood-brain barrier penetration and is mainly used in the study of obesity and related metabolic diseases[1][2][3].

• UNSPSC :

  12352005

• Hazard Statement :

  H302

• Target :

  Neuropeptide Y Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease; Endocrinology

• Assay Protocol :

  https://www.medchemexpress.com/bms-193885.html

• Purity :

  99.91

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(C1=C(C)NC(C)=C(C(OC)=O)C1C2=CC=CC(NC(NCCCN3CCC(C4=CC=CC(OC)=C4)CC3)=O)=C2)OC

• Molecular Formula :

  C33H42N4O6

• Molecular Weight :

  590.71

• Precautions :

  H302

• References & Citations :

  [1]Antal-Zimanyi I, et al. Pharmacological characterization and appetite suppressive properties of BMS-193885, a novel and selective neuropeptide Y (1) receptor antagonist. Eur J Pharmacol. 2008 Aug 20;590 (1-3) :224-32.|[2]Poindexter GS, et al. Dihydropyridine neuropeptide Y Y (1) receptor antagonists. Bioorg Med Chem Lett. 2002 Feb 11;12 (3) :379-82.|[3]Kaczyńska K, et al. NPY Y (1) receptors are involved in cardio-respiratory responses to intravenous injection of neuropeptide Y in anaesthetized rats. Pharmacol Res. 2010 Nov;62 (5) :444-9.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  NPY Y1 receptor

• CAS Number :

  [186185-03-5]