BMS-193885

CAT: 0804-HY-120619-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-120619-01Size:5 mg
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Description
BMS-193885 is a selective neuropeptide Y1 receptor antagonist (Ki=3.3 nM) that competitively blocks the receptor to inhibit NPY-mediated appetite regulation signaling pathways, reduce food intake and inhibit weight gain. BMS-193885 has good blood-brain barrier penetration and is mainly used in the study of obesity and related metabolic diseases[1][2][3].
CAS Number
[186185-03-5]
UNSPSC
12352005
Hazard Statement
H302
Target
Neuropeptide Y Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/bms-193885.html
Purity
99.91
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=C(C)NC(C)=C(C(OC)=O)C1C2=CC=CC(NC(NCCCN3CCC(C4=CC=CC(OC)=C4)CC3)=O)=C2)OC
Molecular Formula
C33H42N4O6
Molecular Weight
590.71
Precautions
H302
References & Citations
[1]Antal-Zimanyi I, et al. Pharmacological characterization and appetite suppressive properties of BMS-193885, a novel and selective neuropeptide Y (1) receptor antagonist. Eur J Pharmacol. 2008 Aug 20;590 (1-3) :224-32.|[2]Poindexter GS, et al. Dihydropyridine neuropeptide Y Y (1) receptor antagonists. Bioorg Med Chem Lett. 2002 Feb 11;12 (3) :379-82.|[3]Kaczyńska K, et al. NPY Y (1) receptors are involved in cardio-respiratory responses to intravenous injection of neuropeptide Y in anaesthetized rats. Pharmacol Res. 2010 Nov;62 (5) :444-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NPY Y1 receptor

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B7327-50BMS 193885
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A18740-5BMS-193885 5mg
A18740-1BMS-193885 1mg
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A18740-25BMS-193885 25mg
A18740-50BMS-193885 50mg
A18740-100BMS-193885 100mg

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