SBI-0640726

• UNSPSC Description:

  SBI-0640726 is an eIF4G1 inhibitor with antiproliferative activity in melanoma. SBI-0640726 disrupts the eIF4F translation initiation complex by inhibiting AKT and NF-kB signaling pathways. SBI-0640726 inhibits the growth of NRAS and BRAF mutant melanoma in vitro[1].

• Target Antigen:

  Akt; Eukaryotic Initiation Factor (eIF); NF-κB

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;NF-κB;PI3K/Akt/mTOR

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/sbi-0640726.html

• Smiles:

  O=C(C1=C(C2=CC=CC=C2)C3=C(C=CC(Cl)=C3)NC1=O)/C=C/C4=CC=CC=N4

• Molecular Weight:

  386.83

• References & Citations:

  [1]Yongmei Feng, et al. "SBI-0640756 attenuates the growth of clinically unresponsive melanomas by disrupting the eIF4F translation initiation complex." Cancer research 75.24 (2015): 5211-5218.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1321827-45-5