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SBI-0640726

CAT: 0804-HY-164524Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-164524Size:1 Each
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Description
SBI-0640726 is an eIF4G1 inhibitor with antiproliferative activity in melanoma. SBI-0640726 disrupts the eIF4F translation initiation complex by inhibiting AKT and NF-kB signaling pathways. SBI-0640726 inhibits the growth of NRAS and BRAF mutant melanoma in vitro[1].
CAS Number
1321827-45-5
UNSPSC
12352005
Target
Akt; Eukaryotic Initiation Factor (eIF) ; NF-κB
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; NF-κB; PI3K/Akt/mTOR
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sbi-0640726.html
Smiles
O=C(C1=C(C2=CC=CC=C2)C3=C(C=CC(Cl)=C3)NC1=O)/C=C/C4=CC=CC=N4
Molecular Formula
C23H15ClN2O2
Molecular Weight
386.83
References & Citations
[1]Yongmei Feng, et al. "SBI-0640756 attenuates the growth of clinically unresponsive melanomas by disrupting the eIF4F translation initiation complex." Cancer research 75.24 (2015) : 5211-5218.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

6-chloro-4-phenyl-3-[(E)-3-pyridin-2-ylprop-2-enoyl]-1H-quinolin-2-one
CAS Number1321827-45-5
PubChem CID5763623
IUPAC Name6-chloro-4-phenyl-3-[(E)-3-pyridin-2-ylprop-2-enoyl]-1H-quinolin-2-one
Molecular FormulaC23H15ClN2O2
Molecular Weight386.8
XLogP4.1
Topological Polar Surface Area59.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Heavy Atom Count28
Formal Charge0
Complexity666
SMILES
C1=CC=C(C=C1)C2=C(C(=O)NC3=C2C=C(C=C3)Cl)C(=O)/C=C/C4=CC=CC=N4
InChI
InChI=1S/C23H15ClN2O2/c24-16-9-11-19-18(14-16)21(15-6-2-1-3-7-15)22(23(28)26-19)20(27)12-10-17-8-4-5-13-25-17/h1-14H,(H,26,28)/b12-10+
InChIKey
KSDWHCKHPLWNBX-ZRDIBKRKSA-N
Chemical Structure
2D Structure
2D structure of 6-chloro-4-phenyl-3-[(E)-3-pyridin-2-ylprop-2-enoyl]-1H-quinolin-2-one
CAS: 1321827-45-5
CID: 5763623
Formula: C23H15ClN2O2
MW: 386.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight386.8
XLogP34.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass386.0822054
Monoisotopic Mass386.0822054
Topological Polar Surface Area59.1 Ų
Heavy Atom Count28
Formal Charge0
Complexity666
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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