SBI-425

CAT: 0804-HY-124756-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-124756-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SBI-425 is an orally active and potent TNAP (tissue-nonspecific alkaline phosphatase) inhibitor (IC50=16 nM) . SBI-425 inhibits TNAP in the vasculature, improving cardiovascular parameters and survival[1][2].
CAS Number
[1451272-71-1]
UNSPSC
12352005
Target
Phosphatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/sbi-425.html
Purity
99.40
Solubility
DMSO : 86.67 mg/mL (ultrasonic)
Smiles
O=C(C1=CC(NS(=O)(C2=CC(Cl)=CC=C2OC)=O)=CN=C1)N
Molecular Formula
C13H12ClN3O4S
Molecular Weight
341.77
References & Citations
[1]Pinkerton AB, et al. Discovery of 5- ((5-chloro-2-methoxyphenyl) sulfonamido) nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor. Bioorg Med Chem Lett. 2018 Jan 1;28 (1) :31-34.|[2]Sheen CR, et al. Pathophysiological role of vascular smooth muscle alkaline phosphatase in medial artery calcification. J Bone Miner Res. 2015 May;30 (5) :824-36.|[3]Brichacek AL, et al. Systemic inhibition of tissue-nonspecific alkaline phosphatase alters the brain-immune axis in experimental sepsis. Sci Rep. 2019 Dec 11;9 (1) :18788.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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