SBI-0087702

• Description :

  SBI-0087702 promots the cytoplasmic localization of ATF2 in melanoma cells. SBI-0087702-induced translocation of ATF2 to the mitochondria results in increased apoptosis due to loss of mitochondrial membrane integrity. SBI-0087702 also inhibits growth and motility of melanoma cells. SBI-0087702 was shown to inhibit ATF2 phosphorylation on Thr52 by PKCε[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H318, H410

• Target :

  PKC

• Related Pathways :

  Epigenetics; TGF-beta/Smad

• Field of Research :

  Cancer

• Purity :

  99.55

• Solubility :

  DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  COC1=CC=C(CCNCC2=C3C=CC=CC3=C(OC)C=C2)C=C1

• Molecular Formula :

  C21H23NO2

• Molecular Weight :

  321.41

• Precautions :

  H318, H410

• References & Citations :

  [1]Tal Varsano, et al. Inhibition of Melanoma Growth by Small Molecules that Promote the Mitochondrial Localization of ATF2. Clin Cancer Res. 2013 May 15;19 (10) :2710-22.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [864431-36-7]