SBI-810

CAT: 0804-HY-164795-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-164795-01Size:5 mg
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Description
SBI-810 is a functionally selected β-arrestin-biased neurotensin receptor 1 (NTSR1) allosteric modulator. SBI-810 modulates NTSR1 G protein signaling in a G protein-specific manner in the presence of the endogenous ligand, neurotensin (NT) . SBI-810 fully antagonizes NT-induced activation of Gq, partially antagonizes NT-induced activation of Gi1 and is permissive of NTSR1 activation of GoA and G12[1][2].
CAS Number
[1849603-79-7]
UNSPSC
12352005
Target
Neurotensin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sbi-810.html
Purity
98.25
Solubility
DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
OCCN(C)C1=CC2=C(N=C(C3(CC3)C)N=C2N4CCC(CC4)C5=C(OC)C=CC=C5)C=C1
Molecular Formula
C27H34N4O2
Molecular Weight
446.58
References & Citations
[1]Lawrence Barak, et al. Compositions for and methods of treating and/or preventing pain. WO2022241186A1. 2022 November 17.|[2]Center M N A, et al. Summer Undergraduate Research Expo[J]. 2014.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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