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SBI-0640726

CAT: 0931-T89836-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T89836-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1321827-45-5
Target
NF-κB, Akt, PERK
Related Pathways
Cytoskeletal Signaling, Apoptosis, NF-κB, PI3K/Akt/mTOR signaling
Bioactivity
SBI-0640726, an eIF4G1 inhibitor, exhibits antiproliferative activity against melanoma. It disrupts the eIF4F translation initiation complex by inhibiting the AKT and NF-kB signaling pathways. Additionally, SBI-0640726 inhibits the growth of melanoma with NRAS and BRAF mutations in vitro.
Smiles
C(/C=C/C1=CC=CC=N1)(=O)C2=C(C=3C(NC2=O)=CC=C(Cl)C3)C4=CC=CC=C4
Molecular Formula
C23H15ClN2O2
Molecular Weight
386.83
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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