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SBI-477

CAT: 0804-HY-124418-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-124418-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SBI-477 is a chemical probe that stimulates insulin signaling by deactivating the transcription factor MondoA. SBI-477 can lead to reduced expression of the insulin pathway suppressors thioredoxin-interacting protein (TXNIP) and arrestin domain-containing 4 (ARRDC4) . SBI-477 coordinately inhibits triacylglyceride (TAG) synthesis and enhances basal glucose uptake in human skeletal myocytes[1].
CAS Number
781628-99-7
UNSPSC
12352005
Target
Arrestin; Fluorescent Dye; Insulin Receptor; LXR
Type
Reference compound
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease; Others; Protein Tyrosine Kinase/RTK; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/sbi-477.html
Concentration
10mM
Purity
98.0
Solubility
DMSO : 65 mg/mL (ultrasonic)
Smiles
O=C(NC1=NC(C2=CC=C(OC)C=C2)=CS1)C3=CC=C(OCC(N4CCOCC4)=O)C(OC)=C3
Molecular Formula
C24H25N3O6S
Molecular Weight
483.54
References & Citations
[1]Ahn B, et al. MondoA coordinately regulates skeletal myocyte lipid homeostasis and insulin signaling. J Clin Invest. 2016 Sep 1;126 (9) :3567-79.|[2]Nakayama, Y., et al., (2024) . Systemic Deletion of ARRDC4 Improves Cardiac Reserve and Exercise Capacity in Diabetes. Circulation research, 135 (3), 416–433.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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Alternative Products

CatalogName
BUP08927-01SBI-477
A18962-50SBI-477 50mg
A18962-500SBI-477 500mg
A18962-1SBI-477 1mg
A18962-25SBI-477 25mg
A18962-5SBI-477 5mg
A18962-100SBI-477 100mg
A18962-10SBI-477 10mg
GTR19168777-01SBI-477 analog
A18962-10mM-DSBI-477 10mM * 1mL in DMSO

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