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Piccolo Antibody

CAT: 0400-SPC-197DSize: 100 µgDry Ice: NoHazardous: No
CAT#:0400-SPC-197DSize:100 µg
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Background
Piccolo (also known as Aczonin) is a large, multidomain scaffolding protein localized at the presynaptic active zone. It plays a central role in organizing the cytomatrix at active zones (CAZ) and coordinating synaptic vesicle trafficking, exocytosis, and endocytosis. Piccolo interacts with proteins involved in actin dynamics and clathrin-mediated endocytosis, including Abp1 and dynamin, thereby regulating synaptic vesicle recycling. It is often co-expressed with Bassoon, another CAZ protein, to maintain synaptic integrity and plasticity. Disruption of Piccolo expression or function has been linked to neurodevelopmental and neurodegenerative disorders, including schizophrenia and Parkinson’s disease. Its role in synaptic maintenance and plasticity makes Piccolo a promising target for understanding and treating synaptic dysfunction in neurological diseases.
Description
Rabbit Anti-Human Piccolo Polyclonal
CAS Number
9007-83-4
Specifications
Detects ~550kDa. No cross-reactivity to Bassoon.
Product Name Alternative
Protein piccolo, Aczonin, PCLO, Presynaptic cytomatrix protein, Multidomain presynaptic cytomatrix protein, Piccolo (presynaptic cytomatrix protein), PCLO_HUMAN, ACZ, Pico, Brain-derived HLMN protein, DKFZp779G1236, KIAA0559, Piccolo mouse homolog of Pico
UNSPSC
12352203
UN Code
Non-hazardous
Hazard Statement
Non-hazardous
Gene ID
27445
Swiss Prot
Q9Y6V0
Accession Number
NP_055325.2
Cellular Locus
Cell Junction | Synapse
Host
Rabbit
Species Reactivity
Human
,
Mouse
,
Rat
Immunogen
Recombinant Full length human Piccolo Protein, BC001304.1
Target
Piccolo
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal
Applications
WB | IHC
Validated Applications
WB
,
IHC
Field of Research
Neuroscience | Cell Markers | Neuron Markers | Presynaptic Markers
Purification
Protein A Purified
Detection Range
1 µg/ml of SPC-197 was sufficient for detection of Piccolo in 10 µg of rat brain tissue lysate by colorimetric immunoblot analysis using goat ant rabbit IgG:HRP as the secondary antibody.
Concentration
1 mg/ml
Dilution
WB (1:1000), IHC (1:400) ; optimal dilutions for assays should be determined by the user.
Weight
0.1
Buffer
PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer changes when conjugated
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Gerber S.H., Garcia J., Rizo J., Sudhof T.C. (2001) EMBO J. 20 (7) : 1605-1619. 2. Wang X., et al. (1999) J Cell Biol. 147 (1) : 151-162. 3. Dresbach T., et al. (2006) J Biol Chem. 281 (9) :6038-6047.
Shipping Conditions
Blue Ice or 4ºC
Storage Conditions
-20ºC
Specificity
Detects ~550kDa. No cross-reactivity to Bassoon.
Species
Human | Mouse | Rat
Location
Cell Junction | Synapse
Immunogen Species
Human

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