AHA1 Antibody

CAT: 0400-SPC-183DSize: 100 µLDry Ice: NoHazardous: No
CAT#:0400-SPC-183DSize:100 µL
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
Activator of HSP90 ATPase Homolog 1 (AHA1) is a critical member of the HSP90 co-chaperone family, known for its role in regulating protein folding and stability. AHA1 enhances the ATPase activity of HSP90, a central molecular chaperone, by competitively displacing other co-chaperones such as p23, thereby accelerating the chaperone cycle and influencing client protein maturation. AHA1 is implicated in endoplasmic reticulum (ER) to Golgi trafficking, a process essential for proper protein sorting and cellular homeostasis. It also interacts with HSP90 (HSPCA) and the cytoplasmic tail of vesicular stomatitis virus glycoproteins (VSV G), suggesting a broader role in viral pathogenesis and intracellular transport mechanisms. Importantly, AHA1 is widely expressed across multiple tissues, including the brain, heart, skeletal muscle, and kidney, with lower expression levels observed in the liver and placenta. Its presence in the central nervous system highlights its potential relevance in neurodegenerative disease pathways, where protein misfolding and aggregation are hallmark features. Emerging evidence suggests that targeting AHA1 may enhance the efficacy of HSP90 inhibitors, positioning it as a promising therapeutic co-target in diseases characterized by proteostasis imbalance, such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease.
Description
Rabbit Anti-Mouse AHA1 Polyclonal
CAS Number
9007-83-4
Specifications
Detects ~ 38kDa.
Product Name Alternative
AHSA1, AHA1, HSPC322, p38, C14orf3, LOC10598, Activator of Hsp90 ATPase activity 1, Activator of 90 kDa heat shock protein ATPase homolog 1
UNSPSC
12352203
UN Code
Non-hazardous
Hazard Statement
Non-hazardous
Gene ID
217737
Swiss Prot
Q8BK64
Accession Number
NP_666148.1
Cellular Locus
Cytoplasm | Endoplasmic Reticulum
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Recombinant Full Length Mouse Aha1 Protein
Target
AHA1
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal
Applications
WB | IHC | ICC/IF | IP | ELISA
Validated Applications
WB, IHC, ICC/IF, IP, ELISA
Field of Research
Cancer | Heat Shock | Cell Signaling | Protein Trafficking | Chaperone Proteins
Purification
Protein A Purified
Detection Range
1 µl/ml of SPC-183 was sufficient for detection of Aha1 in 10 µg of mixed human cell lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Concentration
1 mg/ml
Dilution
WB (1:1000), ICC/IF (1:60) ; optimal dilutions for assays should be determined by the user.
Weight
0.1
Buffer
PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer changes when conjugated
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Hainzl O., Lapina M.C., Buchner J., Richter K. (2009) J Biol Chem. Epub. 2. Harst A., Lin H., Obermann W.M. (2005) Biochem J. 387 (pt.3) : 789-796. 3. Lotz G.P., Brychzy A., Heinz S., Obermann W.M. (2008) J Cell Sci. 121 (pt.5) : 717-723. 4. Holmes J.L., Sharp S.Y., Hobbs S., Workman P. (2008) Cancer Res. 68 (4) : 1188-1197.
Shipping Conditions
Blue Ice or 4ºC
Storage Conditions
-20ºC
Specificity
Detects ~ 38kDa.
Species
Human | Mouse | Rat
Location
Cytoplasm | Endoplasmic Reticulum
Immunogen Species
Mouse

Related Products

CatalogName
SPR-309AAHA1 Protein
SPR-311BAHA1 Protein
SPR-309CAHA1 Protein
SPR-314AAHA1 Protein
SPR-314CAHA1 Protein
SPR-311CAHA1 Protein
SPR-300CAHA1 Protein
SPR-311AAHA1 Protein
SPR-300BAHA1 Protein
SPR-300AAHA1 Protein

Alternative Products

CatalogName
MBS200334-01AHA1 antibody
RQ6997AHSA1 Antibody / AHA1
MBS805647-01Aha1 Antibody: PerCP
MBS800152-01Aha1 Antibody: HRP
MBS800620-01Aha1 Antibody: Biotin
MBS800835-01Aha1 Antibody: RPE
MBS801636-01Aha1 Antibody: FITC
hsp-013AHA1

Popular Products