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NHE3 Antibody

CAT: 0400-SPC-400DSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0400-SPC-400DSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Sodium-hydrogen exchanger 3 (NHE3), encoded by SLC9A3, is a membrane-bound transporter that mediates the electroneutral exchange of intracellular H+ for extracellular Na+. While primarily studied in renal and intestinal physiology, emerging evidence suggests NHE3 may influence neurodegenerative processes through its role in pH regulation, ion homeostasis, and cellular signaling. NHE3 is regulated by phosphorylation via kinases such as PKA, SGK1, and CK2, and its dysregulation may contribute to altered neuronal excitability and glial function. Aberrant NHE3 activity could exacerbate neuroinflammation and oxidative stress, both of which are implicated in Alzheimer’s disease and other neurodegenerative disorders. Understanding NHE3’s role in the brain may reveal novel therapeutic targets for modulating ionic balance and neuroinflammatory responses in neurodegeneration.
Description
Rabbit Anti-Rat NHE3 Polyclonal
CAS Number
9007-83-4
Specifications
Detects ~84kDa.
Product Name Alternative
Sodium / Hydrogen Exchanger 3, SLC9A3, Na+/H+ exchanger 3, isoform 3, Solute carrier family 9 member 3, NHE3MGC126720, MGC126718, solute carrier family 9 (sodium/hydrogen exchanger) member 3, NHE-3, Na (+) /H (+) exchanger 3, Sodium/hydrogen exchanger 3
UNSPSC
12352203
UN Code
Non-hazardous
Hazard Statement
Non-hazardous
Gene ID
24784
Swiss Prot
P26433
Accession Number
NP_036786
Cellular Locus
Membrane
Host
Rabbit
Species Reactivity
Rat, Mouse
Immunogen
Synthetic peptide mapping to AA 809 to 831 of rat sequence
Target
NHE3
Clonality
Polyclonal
Conjugation
Unconjugated
Tissue Specificity
Most abundant in colon and small intestine, followed by kidney and stomach. In kidney, expressed in proximal tubules and outer medulla (at protein level)
Type
Polyclonal
Applications
WB | ICC/IF | IHC
Validated Applications
WB, ICC/IF, IHC
Field of Research
Cell Signaling | Neuroscience | Pumps/Transporters | Ion Pumps/Transporters | Cancer
Purification
Protein A Purified
Detection Range
1 µg/ml of SPC-400 was sufficient for detection of HNE3 in 10 µg of rat kidney tissue lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.
Concentration
1 mg/ml
Dilution
WB (1:1000) ; IHC (1:25) ; optimal dilutions for assays should be determined by the user.
Weight
0.1
Buffer
PBS, 50% glycerol, 0.09% sodium azide *Storage buffer changes when conjugated
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Kim G.H., Ecelbarger C.A., Knepper M.A. and Packer R.K. (1999) J Am Soc Nephrol. 10: 935-942. 2. Dynia D.W., Steinmetz A.G. and Kocinsky H.S. (2010) Am J Physoil Renal Physiol. 298 (3) : F745-F753.
Shipping Conditions
Blue Ice or 4ºC
Storage Conditions
-20ºC
Specificity
Detects ~84kDa.
Species
Rat | Mouse
Location
Membrane
Immunogen Species
Rat

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