HSP110 Antibody

HSP110, a member of the HSP110/SSE family of large stress proteins, plays a critical role in maintaining proteostasis under physiological and pathological conditions. Although distantly related to the HSP70 family, HSP110 shares 30–33% amino acid identity, particularly within the conserved ATP-binding domain, and functions cooperatively with HSP70 in the eukaryotic cytosol to facilitate protein folding and prevent aggregation. In mammals, HSP110 is constitutively expressed, with notably high levels in the brain. Its expression is further upregulated in response to cellular stress, including cerebral ischemia—a condition closely linked to neurodegenerative processes. Both HSP70 and HSP110 are elevated following ischemic events, suggesting a coordinated chaperone response. Interestingly, HSP110 deficiency has been associated with enhanced HSP70 activity, indicating a compensatory mechanism that may influence neuronal survival and recovery. Emerging evidence positions HSP110 as a key modulator of neuroprotection, particularly in the context of diseases characterized by protein misfolding and aggregation, such as Alzheimer’s, Parkinson’s, and Huntington’s disease. By stabilizing protein conformation and supporting cellular stress responses, HSP110 contributes to neuronal resilience and recovery. Beyond neuroscience, HSP110 is also being explored in cancer immunotherapy, highlighting its broader relevance in stress biology and therapeutic development. Its dual role in neuroprotection and immune modulation makes HSP110 a promising target in translational research focused on neurodegenerative disease intervention.

Rabbit Anti-Hamster HSP110 Polyclonal

9007-83-4

Detects ~110kDa.

HSPH1, HSP110, HSP105, Heat shock protein 105 kDa, Heat shock 110 kDa protein, KIAA0201, Heat shock 105kDa alpha, heat shock 105kDa beta, HSP105A, HSP105B, NY CO 25

12352203

Non-hazardous

Non-hazardous

10808

Q92598

NP_006635.2

Cytoplasm

Synthetic peptide derived from the sequence of hamster HSP110; sequence identical to human and mouse

HSP110

Unconjugated

Polyclonal

WB | IHC | ICC/IF

Cancer | Heat Shock | Cell Signaling | Protein Trafficking | Chaperone Proteins

Protein A Purified

1 µg/ml of SPC-195 was sufficient for detection of HSP110 in 10 µg of human cell line mixed lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.

1 mg/ml

WB (1:1000), IHC (1:100) ; optimal dilutions for assays should be determined by the user.

0.012

PBS pH7.2, 50% glycerol, 0.09% sodium azide *Storage buffer changes when conjugated

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

1. Lee-Yoon D., et al. (1995) J Biol Chem. 270: 15725-15733. 2. Dragovic Z., et al. (2006) EMBO J. 25: 2519-2528. 3. Nakamura J., et al. (2008) Stroke. 39 (10) : 2853-2859. 4. Subject D.R. (2001) Health Research Inc. Report number AS90893: 1-84.

Blue Ice or 4ºC

-20ºC

Detects ~110kDa.

Human | Mouse | Rat | Bovine | Monkey | Hamster | Sheep | Yeast | Shark | Gummy Shark (Mustelus antarcticus) | School Shark (Galeorhinus galeus)

Cytoplasm