Piccolo Polyclonal Antibody

CAT: 0498-bs-11354RSize: 100 µLDry Ice: NoHazardous: No
CAT#:0498-bs-11354RSize:100 µL
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Background
Piccolo is 1 component of the presynaptic cytomatrix. Bassoon is a large protein which is also found in the presynaptic compartments of rat brain synapses. Bassoon, along with Piccolo, is part of the ensemble of presynaptic proteins that are involved in orchestrating events at the nerve terminal. Bassoon is found in axon terminals of hippocampal neurons where it is highly concentrated in the vicinity of the active zone. Piccolo has a similar distribution and colocalizes with Bassoon in cultured hippocampal cells. Piccolo zinc fingers interact with the dual prenylated rab3A and VAMP2/ Synaptobrevin II receptor PRA. Bassoon may be involved in cytomatrix organization at the site of neurotransmitter release. The gene which encodes bassoon maps to human chromosome 3p21.31. The gene which encodes piccolo maps to human chromosome 7q21.11.
Synonyms
ACZ; Aczonin; Brain-derived HLMN protein; DKFZp779G1236; KIAA0559; Multidomain presynaptic cytomatrix protein; PCLO; PCLO_HUMAN; Piccolo presynaptic cytomatrix protein; Piccolo, mouse, homolog of antibody Pico; Presynaptic cytomatrix protein; Protein piccolo.
Cellular Locus
Cell membrane
Host
Rabbit
Cross Reactivity
Human
Immunogen
4951-5056/5056
Target
Piccolo
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human Piccolo
Applications
ELISA
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
ELISA (1:500-1000)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
Predicted Cross Reactivity
Mouse, Rat, Dog, Cow, Pig

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