WS-11

• Description :

  WS-11 is a non-covalent reversible BTK inhibitor with IC50s of 3.9 nM and 2.2 nM for wild type, C481S mutation BTK, respectively. WS-11 can form strong π-π interaction with PHE540 and form p-π interaction with LYS430 within the active pocket, besides the strong hydrogen bonds[1].

• UNSPSC :

  12352005

• Target :

  Btk

• Type :

  Reference compound

• Related Pathways :

  Protein Tyrosine Kinase/RTK

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ws-11.html

• Smiles :

  NC1=C2C(C3=CC=C(C=C3F)C(NC4=NC=CC=C4)=O)=NN(C2=NC=N1)C5CCCN(C5)C6=NC(C=C6)=O

• Molecular Formula :

  C26H22FN9O2

• Molecular Weight :

  511.51

• References & Citations :

  BTKIC5050

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2759280-09-4]