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WS-11

CAT: 0804-HY-169228Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-169228Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
WS-11 is a non-covalent reversible BTK inhibitor with IC50s of 3.9 nM and 2.2 nM for wild type, C481S mutation BTK, respectively. WS-11 can form strong π-π interaction with PHE540 and form p-π interaction with LYS430 within the active pocket, besides the strong hydrogen bonds[1].
CAS Number
2759280-09-4
UNSPSC
12352005
Target
Btk
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ws-11.html
Smiles
NC1=C2C(C3=CC=C(C=C3F)C(NC4=NC=CC=C4)=O)=NN(C2=NC=N1)C5CCCN(C5)C6=NC(C=C6)=O
Molecular Formula
C26H22FN9O2
Molecular Weight
511.51
References & Citations
BTKIC5050
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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