WS-11

• Description:

  WS-11 is a non-covalent reversible BTK inhibitor with IC50s of 3.9 nM and 2.2 nM for wild type, C481S mutation BTK, respectively. WS-11 can form strong π-π interaction with PHE540 and form p-π interaction with LYS430 within the active pocket, besides the strong hydrogen bonds[1].

• UNSPSC:

  12352005

• Target:

  Btk

• Type:

  Reference compound

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ws-11.html

• Smiles:

  NC1=C2C (C3=CC=C (C=C3F) C (NC4=NC=CC=C4) =O) =NN (C2=NC=N1) C5CCCN (C5) C6=NC (C=C6) =O

• Molecular Formula:

  C26H22FN9O2

• Molecular Weight:

  511.51

• References & Citations:

  BTKIC5050

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2759280-09-4