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TRPM8 agonist WS-3

CAT: 0804-HY-W014325-01Size: 10 gDry Ice: NoHazardous: No
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CAT#:0804-HY-W014325-01Size:10 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TRPM8 agonist WS-3 is an specific agonist of TRPM8 with an EC50 of 3.7 μM. TRPM8 agonist WS-3 inhibits epileptic seizures through a TRPM8 dependent mechanism. TRPM8 agonist WS-3 can be used for research on epilepsy and other conditions[1][2].
CAS Number
39711-79-0
Product Name Alternative
Framidice 3
UNSPSC
12352211
Hazard Statement
H302, H319
Target
Endogenous Metabolite; TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/trpm8-agonist-ws-3.html
Concentration
10mM
Purity
99.35
Solubility
DMSO : ≥ 100 mg/mL|H2O : < 0.1 mg/mL
Smiles
CC(C)C1CCC(C)CC1C(NCC)=O
Molecular Formula
C13H25NO
Molecular Weight
211.35
Precautions
H302, H319
References & Citations
[1]Behrendt HJ, et al. Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. Br J Pharmacol. 2004 Feb;141 (4) :737-45.|[2]Moriyama H, et al. Anti-seizure effects of WS-3, a TRPM8 agonist, on focal onset seizure mouse model via reduction of extracellular glutamate levels. Neuropsychopharmacology. 2025 Nov;50 (12) :1855-1863.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite

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