WS-917

• Description:

  WS-917 is a potent and orally active ABCB1 modulator. WS-917 enhances ABCB1 ATPase activity. WS-917 significantly enhances the antitumor effect of paclitaxel combined with anti-PD-1 antibody. WS-917 promotes CD8+ T-cell activation[1].

• UNSPSC:

  12352005

• Target:

  P-glycoprotein

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ws-917.html

• Purity:

  99.92

• Smiles:

  O=C1C2=C (NC3=NC (SCC4=NC5=C (S4) C=CC=C5) =NN13) CCC2

• Molecular Formula:

  C16H13N5OS2

• Molecular Weight:

  355.44

• References & Citations:

  [1]Wang S, et al. Cell-Based Screen Identifies a Highly Potent and Orally Available ABCB1 Modulator for Treatment of Multidrug Resistance. J Med Chem. 2024 Oct 19.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, stored under nitrogen)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported