WS-917

• Description :

  WS-917 is a potent and orally active ABCB1 modulator. WS-917 enhances ABCB1 ATPase activity. WS-917 significantly enhances the antitumor effect of paclitaxel combined with anti-PD-1 antibody. WS-917 promotes CD8+ T-cell activation[1].

• UNSPSC :

  12352005

• Target :

  P-glycoprotein

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ws-917.html

• Purity :

  99.92

• Smiles :

  O=C1C2=C(NC3=NC(SCC4=NC5=C(S4)C=CC=C5)=NN13)CCC2

• Molecular Formula :

  C16H13N5OS2

• Molecular Weight :

  355.44

• References & Citations :

  [1]Wang S, et al. Cell-Based Screen Identifies a Highly Potent and Orally Available ABCB1 Modulator for Treatment of Multidrug Resistance. J Med Chem. 2024 Oct 19.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, stored under nitrogen)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported