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WS-383 (free base)

CAT: 0804-HY-126075Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-126075Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
WS-383 free base is a potent, selective and reversible inhibitor of DCN1-UBC12 interaction, with an IC50 of 11 nM. WS-383 free base inhibits Cul3/1 neddylation, induces accumulation of p21, p27 and NRF2[1].
CAS Number
2247543-65-1
UNSPSC
12352005
Target
E1/E2/E3 Enzyme
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ws-383-free-base.html
Solubility
10 mM in DMSO
Smiles
CN(C)CCN1N=NN=C1SC2=CC(C)=NC3=NC(SCC4=CC=C(Cl)C=C4)=NN23
Molecular Formula
C18H20ClN9S2
Molecular Weight
461.99
References & Citations
[1]Wang S, et al. Development of Highly Potent, Selective, and Cellular Active Triazolo[1,5- a]pyrimidine-Based Inhibitors Targeting the DCN1-UBC12 Protein-Protein Interaction.J Med Chem. 2019 Mar 14;62 (5) :2772-2797.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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