WS-11

• Target :

  BTK

• Related Pathways :

  Tyrosine Kinase/Adaptors|||Angiogenesis

• Bioactivity :

  WS-11 is a non-covalent reversible inhibitor of BTK, with IC50 values of 3.9 nM for the wild-type and 2.2 nM for the C481S mutant BTK. In addition to strong hydrogen bonding, WS-11 also forms robust ?-? interactions with PHE540, and p-? interactions with LYS430 within the active pocket.

• Smiles :

  O=C1N=C(C=C1)N2CCCC(N3N=C(C=4C=CC(=CC4F)C(=O)NC5=NC=CC=C5)C=6C(=NC=NC63)N)C2

• Molecular Formula :

  C26H22FN9O2

• Molecular Weight :

  511.51

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2759280-09-4