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WS-11

CAT: 0931-T201126-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T201126-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2759280-09-4
Target
BTK
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis
Bioactivity
WS-11 is a non-covalent reversible inhibitor of BTK, with IC50 values of 3.9 nM for the wild-type and 2.2 nM for the C481S mutant BTK. In addition to strong hydrogen bonding, WS-11 also forms robust π-π interactions with PHE540, and p-π interactions with LYS430 within the active pocket.
Smiles
O=C1N=C(C=C1)N2CCCC(N3N=C(C=4C=CC(=CC4F)C(=O)NC5=NC=CC=C5)C=6C(=NC=NC63)N)C2
Molecular Formula
C26H22FN9O2
Molecular Weight
511.51
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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