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WS-384

CAT: 0804-HY-161470-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-161470-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
WS-384 is a dual LSD1 and DCN1-UBC12 protein-protein interaction inhibitor with oral activity, with IC50 values of 338.79 nM and 14.81 nM, respectively. WS-384 possesses anticancer activity and can cause cell cycle arrest, DNA damage, and induce apoptosis. WS-384 can be used in the research of non-small cell lung cancer (NSCLC) [1].
CAS Number
[2247544-03-0]
UNSPSC
12352005
Target
Apoptosis; Caspase; DNA/RNA Synthesis; E1/E2/E3 Enzyme; Histone Demethylase
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ws-384.html
Purity
98.23
Solubility
DMSO : 17.86 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
BrC1=CC=C(CSC2=NN3C(SC4=NN=NN4CCN(C)C)=CC(C)=NC3=N2)C=C1.Cl
Molecular Formula
C18H21BrClN9S2
Molecular Weight
542.91
References & Citations
[1]Li A, et al. Discovery of WS-384, a first-in-class dual LSD1 and DCN1-UBC12 protein-protein interaction inhibitor for the treatment of non-small cell lung cancer. Biomed Pharmacother. 2024;173:116240.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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