TFEB activator 2

• Description:

  TFEB activator 2 is an orally active compound that can cross the blood-brain barrier. TFEB activator 2 can bind to the dopamine transporter (DAT) . TFEB activator 2 promotes TFEB nuclear translocation and lysosome biogenesis by targeting the DAT-CDK9-TFEB pathway. TFEB activator 2 has neuroprotective activity and can be used in the research of Alzheimer's disease and other diseases[1].

• UNSPSC:

  12352005

• Target:

  Amyloid-β; Autophagy; CDK; Dopamine Transporter

• Type:

  Reference compound

• Related Pathways:

  Autophagy; Cell Cycle/DNA Damage; Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/tfeb-activator-2.html

• Purity:

  98.84

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  FC1=CC2=C(C=C1)NC=C2CCC3C4=C(CCN3CC5CCOCC5)C=C6OCOC6=C4

• Molecular Formula:

  C26H29FN2O3

• Molecular Weight:

  436.52

• References & Citations:

  [1]Jianhui Zhou, et al. Discovery and Optimization of Tetrahydroisoquinoline Derivatives To Enhance Lysosome Biogenesis as Preclinical Candidates for the Treatment of Alzheimer’s Disease. J Med Chem. 2024 Jun 13;67 (11) :8836-8861.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [3027414-04-3]