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TFEB activator 2

CAT: 0804-HY-161724-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-161724-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TFEB activator 2 is an orally active compound that can cross the blood-brain barrier. TFEB activator 2 can bind to the dopamine transporter (DAT) . TFEB activator 2 promotes TFEB nuclear translocation and lysosome biogenesis by targeting the DAT-CDK9-TFEB pathway. TFEB activator 2 has neuroprotective activity and can be used in the research of Alzheimer's disease and other diseases[1].
CAS Number
3027414-04-3
UNSPSC
12352005
Target
Amyloid-β; Autophagy; CDK; Dopamine Transporter
Type
Reference compound
Related Pathways
Autophagy; Cell Cycle/DNA Damage; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tfeb-activator-2.html
Purity
98.84
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC1=CC2=C(C=C1)NC=C2CCC3C4=C(CCN3CC5CCOCC5)C=C6OCOC6=C4
Molecular Formula
C26H29FN2O3
Molecular Weight
436.52
References & Citations
[1]Jianhui Zhou, et al. Discovery and Optimization of Tetrahydroisoquinoline Derivatives To Enhance Lysosome Biogenesis as Preclinical Candidates for the Treatment of Alzheimer’s Disease. J Med Chem. 2024 Jun 13;67 (11) :8836-8861.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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