NF-κΒ activator 2

• Description :

  NF-κΒ activator 2 is a potent and orally active NF- B activator, with an EC50 of 1.58 μM. NF-κΒ activator 2 induces SOD2 through increasing NF- B expression and activation. NF-κΒ activator 2 can be used for the research of amyotrophic lateral sclerosis (ALS) [1].

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319

• Target :

  NF-κB

• Type :

  Reference compound

• Related Pathways :

  NF-κB

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/nf-κ-activator-2.html

• Purity :

  99.76

• Solubility :

  DMSO : 250 mg/mL (ultrasonic)

• Smiles :

  O=C(O)C1=CC=CC(C2=CN=C(NC3=CC=CC=C3F)O2)=C1

• Molecular Formula :

  C16H11FN2O3

• Molecular Weight :

  298.27

• Precautions :

  H315, H319

• References & Citations :

  [1]Mathew B, et, al. Structure-activity relationship (SAR) studies of N- (3-methylpyridin-2-yl) -4- (pyridin-2-yl) thiazol-2-amine (SRI-22819) as NF-ҡB activators for the treatment of ALS. Eur J Med Chem. 2020 Oct 22;112952.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  NF-κB

• CAS Number :

  [2375281-44-8]