NF-κΒ activator 2

• Description:

  NF-κΒ activator 2 is a potent and orally active NF- B activator, with an EC50 of 1.58 μM. NF-κΒ activator 2 induces SOD2 through increasing NF- B expression and activation. NF-κΒ activator 2 can be used for the research of amyotrophic lateral sclerosis (ALS) [1].

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319

• Target:

  NF-κB

• Type:

  Reference compound

• Related Pathways:

  NF-κB

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/nf-κ-activator-2.html

• Purity:

  99.76

• Solubility:

  DMSO : 250 mg/mL (ultrasonic)

• Smiles:

  O=C(O)C1=CC=CC(C2=CN=C(NC3=CC=CC=C3F)O2)=C1

• Molecular Formula:

  C16H11FN2O3

• Molecular Weight:

  298.27

• Precautions:

  H315, H319

• References & Citations:

  [1]Mathew B, et, al. Structure-activity relationship (SAR) studies of N- (3-methylpyridin-2-yl) -4- (pyridin-2-yl) thiazol-2-amine (SRI-22819) as NF-ҡB activators for the treatment of ALS. Eur J Med Chem. 2020 Oct 22;112952.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  NF-κB

• CAS Number:

  [2375281-44-8]