NF-κΒ activator 2

CAT: 0804-HY-134477-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-134477-01Size:5 mg
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Description
NF-κΒ activator 2 is a potent and orally active NF- B activator, with an EC50 of 1.58 μM. NF-κΒ activator 2 induces SOD2 through increasing NF- B expression and activation. NF-κΒ activator 2 can be used for the research of amyotrophic lateral sclerosis (ALS) [1].
CAS Number
[2375281-44-8]
UNSPSC
12352005
Hazard Statement
H315, H319
Target
NF-κB
Type
Reference compound
Related Pathways
NF-κB
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nf-κ-activator-2.html
Purity
99.76
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(O)C1=CC=CC(C2=CN=C(NC3=CC=CC=C3F)O2)=C1
Molecular Formula
C16H11FN2O3
Molecular Weight
298.27
Precautions
H315, H319
References & Citations
[1]Mathew B, et, al. Structure-activity relationship (SAR) studies of N- (3-methylpyridin-2-yl) -4- (pyridin-2-yl) thiazol-2-amine (SRI-22819) as NF-ҡB activators for the treatment of ALS. Eur J Med Chem. 2020 Oct 22;112952.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NF-κB

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