NF-κΒ activator 2

• UNSPSC Description:

  NF-κΒ activator 2 is a potent and orally active NF-?B activator, with an EC50 of 1.58 μM. NF-κΒ activator 2 induces SOD2 through increasing NF-?B expression and activation. NF-κΒ activator 2 can be used for the research of amyotrophic lateral sclerosis (ALS)[1].

• Target Antigen:

  NF-κB

• Type:

  Reference compound

• Related Pathways:

  NF-κB

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/nf-κ-activator-2.html

• Smiles:

  O=C(O)C1=CC=CC(C2=CN=C(NC3=CC=CC=C3F)O2)=C1

• Molecular Weight:

  298.27

• References & Citations:

  [1]Mathew B, et, al. Structure-activity relationship (SAR) studies of N-(3-methylpyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine (SRI-22819) as NF-ҡB activators for the treatment of ALS. Eur J Med Chem. 2020 Oct 22;112952.

• Shipping Conditions:

  Room Temperature

• CAS Number:

  2375281-44-8