TFEB activator 1

• UNSPSC Description:

  TFEB activator 1 is an orally effective, mTOR-independent activator of TFEB. TFEB activator 1 significantly promotes the nuclear translocation of Flag-TFEB with an EC50 of 2167 nM. TFEB activator 1 enhances autophagy without inhibiting the mTOR pathway and has the potential for neurodegenerative diseases treatment[1].

• Target Antigen:

  Autophagy

• Type:

  Reference compound

• Related Pathways:

  Autophagy

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/tfeb-activator-1.html

• Smiles:

  O=C(/C=C/C1=CC=CC=C1OC)/C=C/C2=CC=CC=C2OC

• Molecular Weight:

  294.34

• References & Citations:

  [1]Song JX, et al. A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition. Autophagy. 2016 Aug 2;12(8):1372-89.

• Shipping Conditions:

  Room Temperature

• CAS Number:

  39777-61-2