ISR activator 2

• Description :

  ISR activator 2 is a selective ISR activator. ISR activator 2 can preferentially activate the ISR through the binding of the cytosolic pattern recognition receptor RIG-I, which subsequently activates the heme-regulated inhibitor (HRI) ISR kinase independent of an interferon response. ISR activator 2 can be used for the study of pancreatic cancer[1].

• CAS Number :

  [332874-88-1]

• UNSPSC :

  12352005

• Target :

  Eukaryotic Initiation Factor (eIF)

• Related Pathways :

  Cell Cycle/DNA Damage

• Field of Research :

  Cancer; Neurological Disease

• Smiles :

  CC1=CC(C)=NC(SCC(NC2=C(C(OCC)=O)C(C3=CC=CC=C3)=CS2)=O)=C1C#N

• Molecular Formula :

  C23H21N3O3S2

• Molecular Weight :

  451.56

• References & Citations :

  [1]Cuoco CA, et al. Pharmacological targeting of RIG-I can selectively activate the integrated stress response. Sci Adv. 2025 Oct 31;11 (44) :eadt3014.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported