Products for Research Use Only
RegisterLogin

EF-4-177

CAT: 0804-HY-161690Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-161690Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
EF-4-177 is an orally active and allosteric CDK2 inhibitor with the IC50 of 87 nM. EF-4-177 can disrupt spermatogenesis[1][2].
CAS Number
2891574-93-7
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/ef-4-177.html
Smiles
N#CC1=CC2=C(C(CCNC3=C(C=C(C=C3)S(F)(F)(F)(F)F)C(O)=O)=CN2)C=C1
Molecular Formula
C18H14F5N3O2S
Molecular Weight
431.38
References & Citations
[1]Faber EB, et al. Screening through Lead Optimization of High Affinity, Allosteric Cyclin-Dependent Kinase 2 (CDK2) Inhibitors as Male Contraceptives That Reduce Sperm Counts in Mice. J Med Chem. 2023;66 (3) :1928-1940. |[2]Huang Y, et al. Targeting cyclin-dependent kinases: From pocket specificity to drug selectivity. Eur J Med Chem. Published online May 29, 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK2

Related Products

CatalogName
HY-120107OAT-177
HY-151335-01KU-177
HY-178283EGFR-IN-177
HY-D1139Pigment red 177
HY-161051Anticancer agent 177
HY-161841Antitumor agent-177
HY-D0625Disperse Red 177
HY-U00118-01EF-5
HY-P7343-01FGF-12, Human (177 a.a)
HY-118931EF-1502

Alternative Products

CatalogName
T88162-01EF-4-177
T63273-01KU-177
T70177-01OAT-177
020773RTI-177
MBS5776518BHF-177
6979/50SEN 177
MBS5812316MS-177
FK179029-01K-177
sc-136297Paxillin (177)
sc-376019EF-1 ε1 (E-4)

Popular Products