KU-177

CAT: 0804-HY-151335-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-151335-01Size:1 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
KU-177 is a potent inhibitor of Hsp90 ATPase homologue 1 (Aha1), ablates Aha1-driven enhancement of Hsp90-dependent tau aggregation. KU-177 also disrupts Aha1/Hsp90 interactions (IC50=4.08 μM) without inhibition of Hsp90’s ATPase activity. KU-177 can be used for tauopathies research[1][2].
CAS Number
[1160952-43-1]
UNSPSC
12352005
Target
HSP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ku-177.html
Solubility
10 mM in DMSO
Smiles
COC1=CC(C2=C(C=CC(C(NC3=CC4=CC=C(C(OC)=C4OC3=O)OC(C)=O)=O)=C2)OC)=CC=C1
Molecular Formula
C27H23NO8
Molecular Weight
489.47
References & Citations
[1]Gu C, et al. AHSA1 is a promising therapeutic target for cellular proliferation and proteasome inhibitor resistance in multiple myeloma. J Exp Clin Cancer Res. 2022 Jan 6;41 (1) :11. |[2]Keegan BM, et al. Synthesis and Evaluation of Small Molecule Disruptors of the Aha1/Hsp90 Complex for the Reduction of Tau Aggregation. ACS Med Chem Lett. 2022 Apr 15;13 (5) :827-832.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HSP90

Related Products

CatalogName
HY-178283EGFR-IN-177
HY-120107OAT-177
HY-123232-01KU-0058684
HY-105211KU-2285
HY-50710-01KU-0063794
HY-11006-01KU-57788
HY-12061-01KU-60019
HY-136489-01KU-0058948
HY-13431-01KU-0060648
HY-108248KU-32

Alternative Products

CatalogName
MF-0097706-01KU-177
6979/50SEN 177
MBS5812719OAT-177
MBS5776518BHF-177
020773RTI-177
MBS5812316MS-177
sc-136297Paxillin (177)
MBS3604706-01KU-57788
MBS387692-01KU 0060648
WGC308044-10mgKU-60019

Popular Products