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OAT-177

CAT: 0804-HY-120107Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-120107Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
OAT-177 is a potent dual inhibitor targeting acidic mammalian chitinase (AMCase) and chitotriosidase (CHIT1) with an IC50=14.2 nM for human AMCase and IC50=232 nM for human CHIT1. OAT-177 is promising for research of chronic inflammatory and fibrotic-related lung diseases such as asthma and idiopathic pulmonary fibrosis[1].
CAS Number
1799548-33-6
UNSPSC
12352005
Target
Parasite
Related Pathways
Anti-infection
Field of Research
Inflammation/Immunology
Smiles
CC(C)CN(CCC1=CC=C(Cl)C=C1)C2CCN(C3=NC(N)=NN3)CC2
Molecular Formula
C19H29ClN6
Molecular Weight
376.93
References & Citations
[1]Koralewski R, et al. Discovery of OATD-01, a First-in-Class Chitinase Inhibitor as Potential New Therapeutics for Idiopathic Pulmonary Fibrosis. J Med Chem. 2020 Dec 24;63 (24) :15527-15540.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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