OAT-177

• Description:

  OAT-177 is a potent dual inhibitor targeting acidic mammalian chitinase (AMCase) and chitotriosidase (CHIT1) with an IC50=14.2 nM for human AMCase and IC50=232 nM for human CHIT1. OAT-177 is promising for research of chronic inflammatory and fibrotic-related lung diseases such as asthma and idiopathic pulmonary fibrosis[1].

• UNSPSC:

  12352005

• Target:

  Parasite

• Related Pathways:

  Anti-infection

• Field of Research:

  Inflammation/Immunology

• Smiles:

  CC(C)CN(CCC1=CC=C(Cl)C=C1)C2CCN(C3=NC(N)=NN3)CC2

• Molecular Formula:

  C19H29ClN6

• Molecular Weight:

  376.93

• References & Citations:

  [1]Koralewski R, et al. Discovery of OATD-01, a First-in-Class Chitinase Inhibitor as Potential New Therapeutics for Idiopathic Pulmonary Fibrosis. J Med Chem. 2020 Dec 24;63 (24) :15527-15540.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1799548-33-6]