EF-5

• Description :

  EF-5 (EF5; 2-Nitroimidazole) is a hypoxia labeling agent used to identify hypoxia in cells.

• UNSPSC :

  12352005

• Target :

  Biochemical Assay Reagents

• Type :

  Reference compound

• Related Pathways :

  Others

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/EF-5.html

• Purity :

  98.29

• Solubility :

  DMSO : 125 mg/mL (ultrasonic)

• Smiles :

  O=C(NCC(F)(F)C(F)(F)F)CN1C=CN=C1[N+]([O-])=O

• Molecular Formula :

  C8H7F5N4O3

• Molecular Weight :

  302.16

• References & Citations :

  [1]Wang J, et al. The 2-nitroimidazole EF5 is a biomarker for oxidoreductases that activate the bioreductive prodrug CEN-209 under hypoxia. Clin Cancer Res. 2012 Mar 15;18 (6) :1684-95.|[2]Evans SM, et al. Identification of hypoxia in cells and tissues of epigastric 9L rat glioma using EF5 [2- (2-nitro-1H-imidazol-1-yl) -N- (2,2,3,3,3-pentafluoropropyl) acetamide]. Br J Cancer. 1995 Oct;72 (4) :875-82.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• CAS Number :

  [152721-37-4]