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CL-13

CAT: 0804-HY-168301Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168301Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CL-13 is a butyrylcholinesterase (BChE) inhibitor, with an IC50 of 1.15 μM, and a selectivity index (SI) of 9.2 for acetylcholinesterase. CL-13 shows antioxidant activity in SH-SY5Y cells (DPPH EC50 = 47.01 μM) and has the ability to chelate metals involved in Aβ aggregation and/or oxidative stress, showing no neurotoxicity at 50 μM. CL-13 can reverse cognitive impairment caused by scopolamine without affecting the mice's motor skills[1].
UNSPSC
12352005
Target
Amyloid-β; Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cl-13.html
Smiles
S=C(N/N=C/C1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1)NC2=C(C=CC=C3)C3=NC4=CC=CC=C42
Molecular Formula
C29H32N4OS
Molecular Weight
484.66
References & Citations
[1]Gleyton Leonel Silva Sousa, et al. Discovery of novel thiosemicarbazone-acridine targeting butyrylcholinesterase with antioxidant, metal complexing and neuroprotector abilities as potential treatment of Alzheimer's disease: In vitro, in vivo, and in silico studies. Eur J Med Chem. 2025 Jan 5:281:117030.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BChE

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