CL 277082

• Description:

  CL 277082 is a potent and selective acyl CoA:cholesterol acyltransferase (ACAT) inhibitor in microsomes. CL 277082 inhibits ACAT with IC50 values of 0.14 μM for intestinal mucosal microsomes, 0.74 μM for liver, and 1.18 μM for rat adrenal. CL 277082 is a ACAT-catalyzed cholesterol esterification and cholesterol absorption inhibitor[1].

• UNSPSC:

  12352005

• Target:

  Acyltransferase

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Metabolic Disease

• Smiles:

  O=C (NC1=CC=C (F) C=C1F) N (CC2=CC=C (CC (C) (C) C) C=C2) CCCCCCC

• Molecular Formula:

  C26H36F2N2O

• Molecular Weight:

  430.57

• References & Citations:

  [1]Largis EE, et al. CL 277,082: a novel inhibitor of ACAT-catalyzed cholesterol esterification and cholesterol absorption. J Lipid Res. 1989 May;30 (5) :681-90.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 1

• CAS Number:

  96224-26-9