CL 218872

• Description:

  CL 218872 is an orally active and selective ligand for the benzodiazepine receptor subtype BZ1. CL 218872 exhibits anxiolytic, sedative and anticonvulsant activities. CL 218872 can be used in researches of anxiety related disorders and epilepsy[1][2][3][4][5].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  GABA Receptor

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/cl-218872.html

• Purity:

  99.25

• Solubility:

  DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  FC (C1=CC (C2=NN3C (C=C2) =NN=C3C) =CC=C1) (F) F

• Molecular Formula:

  C13H9F3N4

• Molecular Weight:

  278.24

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Squires RF, et al. Some properties of brain specific benzodiazepine receptors: new evidence for multiple receptors. Pharmacol Biochem Behav. 1979 May;10 (5) :825-30. |[2]Oakley NR, et al. The benzodiazepine receptor ligand CL218,872 has both anxiolytic and sedative properties in rodents. Neuropharmacology. 1984 Jul;23 (7A) :797-802.|[3]File SE, et al. The sedative effects of CL 218,872, like those of chlordiazepoxide, are reversed by benzodiazepine antagonists. Psychopharmacology (Berl) . 1985;85 (3) :295-300. |[4]Gee KW, et al. CL 218872 antagonism of diazepam induced loss of righting reflex: evidence for partial agonistic activity at the benzodiazepine receptor. Life Sci. 1983 Feb 28;32 (9) :1037-40.|[5]McNamara RK, et al. Like diazepam, CL 218,872, a selective ligand for the benzodiazepine omega 1 receptor subtype, impairs place learning in the Morris water maze. Psychopharmacology (Berl) . 1992;107 (2-3) :347-51.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  66548-69-4