Indazole-Cl

CAT: 0804-HY-137004Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-137004Size:1 mg
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AVAILABILITY: InStock
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Description
Indazole-Cl (Ind-Cl) is an Estrogen receptor (ER) -β-specific agonist with inflammatory effect. Indazole-Cl inhibits cyclooxygenase-2 exression reduction induced by hypoxia. And Indazole-Cl inhibits ROS production. Indazole-Cl also inhibits cell migration and invasion by hypoxia increased by hypoxia. Indazole-Cl is potent inhibitor of hypoxia-induced inflammation in vascular smooth muscle cells (VSMCs) [1].
CAS Number
[848142-62-1]
Product Name Alternative
Ind-Cl
UNSPSC
12352005
Hazard Statement
H302
Target
COX; Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Immunology/Inflammation; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/indazole-cl.html
Purity
98.72
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=CC2=C(Cl)N(C3=CC=C(O)C=C3)N=C2C=C1
Molecular Formula
C13H9ClN2O2
Molecular Weight
260.68
Precautions
H302
References & Citations
[1]Park C, et al. Indazole-Cl inhibits hypoxia-induced cyclooxygenase-2 expression in vascular smooth muscle cells. J Mol Endocrinol. 2019 Jul 1;63 (1) :27-38.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
COX-2

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