Indazole-Cl

• UNSPSC Description:

  Indazole-Cl (Ind-Cl) is an Estrogen receptor (ER)-β-specific agonist with inflammatory effect. Indazole-Cl inhibits cyclooxygenase-2 exression reduction induced by hypoxia. And Indazole-Cl inhibits ROS production. Indazole-Cl also inhibits cell migration and invasion by hypoxia increased by hypoxia. Indazole-Cl is potent inhibitor of hypoxia-induced inflammation in vascular smooth muscle cells (VSMCs)[1].

• Target Antigen:

  COX; Estrogen Receptor/ERR

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation;Vitamin D Related/Nuclear Receptor

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/indazole-cl.html

• Purity:

  98.72

• Solubility:

  10 mM in DMSO

• Smiles:

  OC1=CC2=C(Cl)N(C3=CC=C(O)C=C3)N=C2C=C1

• Molecular Weight:

  260.68

• References & Citations:

  [1]Park C, et al. Indazole-Cl inhibits hypoxia-induced cyclooxygenase-2 expression in vascular smooth muscle cells. J Mol Endocrinol. 2019 Jul 1;63(1):27-38.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, stored under nitrogen)

• Clinical Information:

  No Development Reported

• CAS Number:

  848142-62-1