Cl-HIBO

• Description :

  Cl-HIBO is a highly subtype-selective GluR1/2 agonist (EC50=4.7 and 1.7 μM, respectively) . Cl-HIBO is a potent AMPA receptor agonist (IC50=0.22 μM) . Cl-HIBO has desensitizing properties[1].

• UNSPSC :

  12352005

• Target :

  IGluR

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/cl-hibo.html

• Purity :

  99.0

• Solubility :

  H2O : 4.5 mg/mL (ultrasonic; warming)

• Smiles :

  O=C(O)C(N)CC(ON1)=C(Cl)C1=O

• Molecular Formula :

  C6H7ClN2O4

• Molecular Weight :

  206.58

• References & Citations :

  [1]Bjerrum EJ, et al. Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS) -2-amino-3- (4-chloro-3-hydroxy-5-isoxazolyl) propionic acid (Cl-HIBO) . J Med Chem. 2003;46 (11) :2246-2249.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  AMPA Receptor

• CAS Number :

  [909400-43-7]