Cl-HIBO

CAT: 0804-HY-103229Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-103229Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cl-HIBO is a highly subtype-selective GluR1/2 agonist (EC50=4.7 and 1.7 μM, respectively) . Cl-HIBO is a potent AMPA receptor agonist (IC50=0.22 μM) . Cl-HIBO has desensitizing properties[1].
CAS Number
[909400-43-7]
UNSPSC
12352005
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cl-hibo.html
Purity
99.0
Solubility
H2O : 4.5 mg/mL (ultrasonic; warming)
Smiles
O=C(O)C(N)CC(ON1)=C(Cl)C1=O
Molecular Formula
C6H7ClN2O4
Molecular Weight
206.58
References & Citations
[1]Bjerrum EJ, et al. Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS) -2-amino-3- (4-chloro-3-hydroxy-5-isoxazolyl) propionic acid (Cl-HIBO) . J Med Chem. 2003;46 (11) :2246-2249.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AMPA Receptor

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