MI-1904

• Description :

  MI-1904 is the inhibitor for matriptase/TMPRSS2, that exhibits antiviral activity against influenza virus H1N1 and H9N2. MI-1904 blocks the cleavage of glycoproteins on the viral surface, prevents the virus from binding to host cell receptors, and thus inhibits the entry and replication of the virus[1].

• CAS Number :

  [3033379-90-4]

• UNSPSC :

  12352005

• Target :

  Influenza Virus; SARS-CoV; Ser/Thr Protease

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Metabolic Enzyme/Protease

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/mi-1904.html

• Smiles :

  O=S(C1=CC=CC(C2=CC=C(CO)C(F)=C2)=C1)(N[C@@H](CC3=CC(C(N)=N)=CC=C3)C(N4CCC(NC(NC(C)(C)C)=O)CC4)=O)=O

• Molecular Formula :

  C33H41FN6O5S

• Molecular Weight :

  652.78

• References & Citations :

  [1]Gamba D, et al., PK/PD investigation of antiviral host matriptase/TMPRSS2 inhibitors in cell models. Sci Rep. 2024 Jul 18;14 (1) :16621.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported