MI-503

• Description:

  MI-503 is a highly potent and orally bioavailable small molecule inhibitor of the menin-mLL interaction.

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H335

• Target:

  Epigenetic Reader Domain

• Type:

  Reference compound

• Related Pathways:

  Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/MI-503.html

• Purity:

  99.87

• Solubility:

  DMSO : 25 mg/mL (ultrasonic)

• Smiles:

  FC(F)(F)CC(S1)=CC2=C1N=CN=C2NC3CCN(CC4=CC=C(N(CC5=CNN=C5)C(C#N)=C6)C6=C4C)CC3

• Molecular Formula:

  C28H27F3N8S

• Molecular Weight:

  564.63

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]Borkin D, et al. Pharmacologic inhibition of the Menin-MLL interaction blocks progression of MLL leukemia in vivo. Cancer Cell. 2015 Apr 13;27 (4) :589-602.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1857417-13-0]