ADH-503

CAT: 0804-HY-15701B-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-15701B-01Size:5 mg
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AVAILABILITY: InStock
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Description
ADH-503 ((Z) -Leukadherin-1 choline) is an orally active and allosteric CD11b agonist. ADH-503 leads to the repolarization of tumor-associated macrophages, reduction in the number of tumor-infiltrating immunosuppressive myeloid cells, and enhances dendritic cell responses[1].
CAS Number
[2055362-74-6]
Product Name Alternative
(Z) -Leukadherin-1 (choline)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Complement System
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/adh-503.html
Purity
98.04
Solubility
DMSO : 21.43 mg/mL (ultrasonic) |Ethanol : 3.33 mg/mL (ultrasonic; warming; heat to 60°C) |Methanol : 100 mg/mL (ultrasonic)
Smiles
O=C([O-])C1=CC=C(C2=CC=C(/C=C(SC(N3CC4=CC=CC=C4)=S)/C3=O)O2)C=C1.OCC[N+](C)(C)C
Molecular Formula
C27H28N2O5S2
Molecular Weight
524.65
Precautions
H302, H315, H319, H335
References & Citations
[1]Panni RZ, et al. Agonism of CD11b reprograms innate immunity to sensitize pancreatic cancer to immunotherapies. Sci Transl Med. 2019 Jul 3;11 (499) .
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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