NCT-503

• Description:

  NCT-503 is a phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 2.5 µM.

• UNSPSC:

  12352005

• Hazard Statement:

  H315

• Target:

  Phosphoglycerate Dehydrogenase (PHGDH)

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/NCT-503.html

• Concentration:

  10mM

• Purity:

  99.69

• Solubility:

  DMSO : 50 mg/mL (ultrasonic) |Ethanol : 13.33 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  S=C(N1CCN(CC2=CC=C(C(F)(F)F)C=C2)CC1)NC3=NC(C)=CC(C)=C3

• Molecular Formula:

  C20H23F3N4S

• Molecular Weight:

  408.48

• Precautions:

  H315

• References & Citations:

  [1]Pacold ME, et al. A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nat Chem Biol. 2016 Jun;12 (6) :452-8.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1916571-90-8]