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JAM3 rabbit pAb

CAT: 0855-ES9186-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES9186-02Size:100 µL
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Background
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. Unlike other proteins in this family, the this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions. The encoded protein is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family. A mutation in an intron of this gene is associated with hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts. Alternative splicing results in multiple transcript variants.[provided by RefSeq
Description
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. Unlike other proteins in this family, the this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions. The encoded protein is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family. A mutation in an intron of this gene is associated with hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts. Alternative splicing results in multiple transcript variants. [provided by RefSeq,
UniProt
Q9BX67
Swiss Prot
Q9BX67
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human protein . at AA range: 60-140
Target
JAM3
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Buffer
-20°C/1 year
Molecular Weight
34kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
34kD
Fragment
IgG
Subcellular Location
Cell membrane ; Single-pass type I membrane protein . Cell junction . Cell junction, desmosome . Cell junction, tight junction . Detected in the acrosome region in developing spermatids (By similarity) . In epithelial cells, it is expressed at desmosomes but not at tight junctions (PubMed:15194813) . Localizes at the cell surface of endothelial cells; treatment of endothelial cells with vascular endothelial growth factor stimulates recruitment of JAM3 to cell-cell contacts (PubMed:15994945) . .; [Soluble form of JAM-C]: Secreted .
Gene ID (Human)
83700

UniProtKB · Q9BX67

Junctional adhesion molecule C

JAM3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9BX67
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
JAM3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
JAM-C
EC number
—
Processing
Precursor
Secondary accessions
B3KWG9, Q8WWL8, Q96FL1
Protein keywords

Coding sequence diversity

Alternative splicing

Biological process

AngiogenesisCell adhesionDifferentiationSpermatogenesis

Cellular component

Cell junctionCell membraneMembraneSecretedTight junction

Technical term

Direct protein sequencingProteomics identificationReference proteome

Disease

Disease variant

PTM

Disulfide bondGlycoproteinLipoproteinPalmitate

Domain

Immunoglobulin domainSignalTransmembraneTransmembrane helix

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