NBR1 Rabbit rabbit pAb

CAT: 0855-ES20659-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0855-ES20659-01Size:50 µL

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Background

The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]

Description

The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21. 1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014],

UniProt

Q14596

Swiss Prot

Q14596

Reactivity

Human; Mouse; Rat

Immunogen

Recombinant Protein of NBR1

Clonality

Polyclonal

Source

Rabbit

Applications

IHC; IF

Concentration

1 mg/ml

Dilution

IHC-p 1:50-300

Molecular Weight

120kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

120kD

Fragment

IgG

Subcellular Location

Cytoplasm . Cytoplasmic vesicle, autophagosome . Lysosome . Cytoplasm, myofibril, sarcomere, M line . In cardiac muscles localizes to the sarcomeric M line (By similarity) . Is targeted to lysosomes for degradation (PubMed:19250911) . .

Other Product Names

Next to BRCA1 gene 1 protein (Cell migration-inducing gene 19 protein; Membrane component chromosome 17 surface marker 2; Neighbor of BRCA1 gene 1 protein; Protein 1A1-3B)

Gene ID (Human)

4077

UniProtKB · Q14596

Next to BRCA1 gene 1 protein

NBR1_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q14596
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: NBR1
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: Q13173, Q15026, Q5J7Q8, Q96GB6, Q9NRF7

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmCytoplasmic vesicleLysosome

Biological process

Host-virus interaction

Ligand

Metal-bindingZinc

PTM

PhosphoproteinUbl conjugation

Domain

Zinc-finger

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